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Program
The format of each ISN Nexus Symposium program adheres to the Nexus
principle of linking research to practice. With a clear emphasis
on maximizing focus, exchange and results, each program is evenly
balanced between the basic, the clinical, and the translational level – the
ultimate phase in bridging the bench to bedside gap. Three sessions
are dedicated to each level, flanked by the series of morning and
afternoon plenaries, along with poster sessions and discussions as
well as industry symposia led
by the ISN Nexus partners.
| Time |
Thursday,
November 29, 2007 |
| 17:00
- 18:00 |
Opening Plenary
Lecture 1
Renal-Pressure Natriuresis - An Infinite Gain Feedback
Mechanism for Long-Term Blood Pressure Regulation?
Keynote Speaker: John E. Hall, USA |
| 18.00
- 20.00 |
Opening Reception |
|
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| Time |
Friday,
November 30, 2007 |
| 09:00
- 10:00 |
Plenary Lecture 2
Disease Genomics and the HapMap
Project
Aravinda Chakravarti, USA |
| 10:00
- 10:30 |
Coffee & Networking Break
|
| 10:30
- 12:00 |
Basic
Science Sessions 1
|
Clinical
Sessions 1 |
RAAS
and Cardiovascular Risk
Chair: David G. Warnock, USA
- Paracrine Factors in Tubuloglomerular Feedback
and Renin Secretion
Jurgen
Schnermann, USA
- ACE2: Linking the RAS to
SARS Infections and Amino Acid Metabolism
Josef
M. Penninger, Austria
- Translational Research
Goes Both Ways: Lessons for Basic Biology from Clinical
Trials
John Funder,
Australia
|
RAAS
and Cardiovascular Risk
Chair: Luis Ruilope, Spain
- Improved Assessment of Cardiovascular Risk by Measurements of Office, Home and Ambulatory Blood Pressure
Giuseppe
Mancia, Italy
- Renin: Friend or Foe?
Morris Brown, UK
- Endothelial Function and Dysfunction: Testing and Clinical
Relevance
Ton Rabelink, The
Netherlands
|
| 12:00 - 12:15 |
Session Break |
| 12:15
- 13:15 |
Industry
Symposium |
| 13:15
- 14:00 |
Lunch & Networking
Break |
| 14:00
- 15:00 |
Poster
Session & Discussion
|
| 15:00
- 16:30 |
Translational
Sessions 1
|
Guyton’s
Concept 2007
- Linking Genomic Pathways to Complex Guytonian Model Systems
of Cardiovascular Function
Allen
Cowley, USA
- A Critical Role for Renal Angiotensin Receptors in the Pathogenesis
of Hypertension
Thomas Coffman, USA
-
Blood Pressure Control - Special Role of ENaC and Body
Fluids
Bernard Rossier, Switzerland
|
| 16:30 - 17:00 |
Coffee & Networking
Break |
| 17:00
- 18:00 |
Plenary Lecture
3
Proteomics of Renal Exosomes
Mark Knepper, USA |
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| Time |
Saturday,
December 1, 2007 |
| 09:00
- 10:00 |
Plenary Lecture 4
The Developmental Origins
of Hypertension
David JP Barker, UK |
| 10:00
- 10:30 |
Coffee & Networking Break
|
| 10:30
- 12:00 |
Basic
Science Sessions 2 |
Proteinuria
and Hypertension
Chair: Bernard Rossier, Switzerland
- Genetics of Steroid-Resistant Nephrotic Syndrome
Corinne Antignac,
France
- Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria
Karl
Tryggvason, Sweden
- Chloride Channel Diseases Resulting from
Impaired Transepithelial Transport or Vesicular Function
Thomas
Jentsch, Germany
|
| 12:00
- 12:45 |
Poster
Session & Discussion |
| 12:45
- 13:45 |
Lunch & Networking
Break
|
| 13:45
- 15:15 |
Clinical Sessions 2 |
Proteinuria
and Hypertension
Chair: Morris Brown, UK
- The Meaning of Albuminuria in Essential Hypertension
Luis Ruilope, Spain
- Aldosterone as Proteinuric and Cardiovascular Risk in Metabolic Syndrome - From Bench to Clinic
Toshiro Fujita, Japan
- Albuminuria, a Separate Target for Treatment
in Hypertension
Dick de Zeeuw, The Netherlands
|
| 15:15 - 15:45 |
Coffee & Networking Break |
| 15:45
- 17:15 |
Translational
Sessions 2 |
Salt - Regulating Effectors
Chair: George Bakris, USA
- Neural Regulation of Renal Tubular Sodium Reabsorption
Gerald
DiBona, USA
- Renalase is a Novel Monoamine Oxidase that Regulates Cardiac
Function and Blood Pressure
Gary
V. Desir, USA
- Oxidative Stress and Nitric Oxide Deficiency in the Kidney:
a Critical Link to Hypertension?
Christopher
Wilcox, USA
|
| 17:15
- 18:15 |
Plenary Lecture 5
Circadian Control of Genes, Cells,
and Organs
Ueli Schibler, Switzerland |
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| Time |
Sunday,
December 2, 2007 |
| 09:00
- 10:30 |
Moderated Discussion
Salt and Hypertension
Chair: David G. Warnock, USA
- Renal Sodium Handling and Night-Time Blood Pressure
Michel
Burnier, Switzerland
- Ethnic Differences in Proximal and Distal Tubular Sodium Reabsorption
in Black and White Populations
Jan Staessen, Belgium
- Effect of Salt Intake on Progression of Chronic Kidney Disease
Paul
Sanders, USA
- Human Hypertension Caused by Mutation in WNK Kinases
Xavier
Jeunemaitre, France
|
| 10:30
- 11:00 |
Coffee & Networking Break
|
| 11:00
- 12:30 |
Basic
Science Sessions 3
|
Clinical
Sessions 3 |
Diuretics
Revisited
Chair: Toshiro Fujita, Japan
- Renal Potassium Channels - Implications for Diuretic Use
Steven
C. Hebert, USA
- The Renal Na-Cl Cotransporter, NCC: a Key Protein in the Regulation
of Blood Pressure
Gerardo Gamba,
Mexico
- The Epithelial Sodium Channel ENaC as Drug Target for Diuretics
Laurent
Schild, Switzerland
|
Diuretics
Revisited
Chair: Jan Staessen, Belgium
- Genetic Modulation of Dietary on Pharmacologic Sodium Restriction
David
Geller, USA
- Inhibition of ENaC in Antihypertensive Treatment
J. Howard
Pratt, USA
- Long-Term Effects of Spironolactone in Patients with Chronic
Renal Dysfunction
Vito Campese, USA
|
| 12:30
- 13:30 |
Lunch & Networking
Break |
| 13:30
- 15:00 |
Translational
Sessions 3 |
New
Methods and Directions
Chair: John Funder, Australia
- NMR Fragment Screening: Tackling Protein-Protein Interaction
Targets
Hartmut Oschkinat, Germany
- 2-Photon Microscopy of the Kidney: Seeing is Believing
Bruce
Molitoris, USA
- Neural Control of Cardiovascular Function
David Robertson,
USA
|
| 15:00
- 15:15 |
Closing Remarks |
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