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Program
The format of each ISN Nexus Symposium program
will adhere to the Nexus principle of linking research to
practice. With a clear emphasis on maximizing focus, exchange
and results, each program will be evenly balanced between
the basic, the clinical, and the translational level – the
ultimate phase in bridging the bench to bedside gap.
Three sessions will be dedicated to each level, flanked
by the series of morning and afternoon plenaries, along with
poster sessions and discussions as well as special pre- lunch
and early evening industry symposia led by the ISN Nexus
partners.
| Time |
Thursday, October 12, 2006 |
| 12:00 - 17:00 |
Arrival & Registration |
| 17.00 - 17.15 |
Welcome Address: William G. Couser, Tilman B. Drüeke |
| 17:15 - 18.15 |
Opening Plenary
Lecture 1
New challenges in calcium and phosphate
metabolism
Keith Hruska |
| 18.15 - 20.00 |
Opening Reception |
|
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| Time |
Friday,
October 13, 2006 |
| 08.30 - 09.30 |
Plenary
Lecture 2
Physiology of renal and intestinal
divalent ion transport
René Bindels |
| 09:30
- 10:00 |
Coffee & Networking
Break
|
| 10:00 - 11:30 |
Basic
Science Sessions 1
|
Clinical
Sessions 1 |
Transporters (structure – function interactions,
proteins)
Chair: René Bindels
- The epithelial calcium channels: uniquely regulated gatekeepers
René Bindels
- Epithelial phosphate transporters
Jürg Biber
- Is Paracellin-1 (CLAUDIN-16) only involved in cation transport?
Martin Konrad
|
Genetic diseases of bone and kidney
Chair: Gérard Friedlander
- The role of the PTH/PTHrP receptor in health and disease
Caroline Silve
- ClC-7 and Ostm1: an ion transport complex important for osteoclasts
and lysosomes of the CNS and the kidney
Thomas J Jentsch
- Disorders of alkaline phosphatases and bone/mineral disease
Michael P Whyte
|
| 11:30 - 12:30 |
Amgen
Symposium : New horizons in the treatment of bone disease: CKD-MBD osteoporosis |
| 12:30 - 13:30 |
Lunch & Networking
Break |
| 13.30
- 14.30 |
Poster
Session & Discussion
|
| 14.30 - 16:00 |
Translational
Sessions 1
|
Urinary
infection & nephrolithiasis
Chair: David Bushinsky
- Tamm-Horsfall protein-Uromodulin:
new ideas about an old molecule
Olivier Devuyst
- Hypercalciuria: from animal models to human
disease
David Bushinsky
- Sodium phosphate transporters, nephrolithiasis
and bone demineralization
Dominique Prié
|
| 16:00 - 16:30 |
Coffee & Networking
Break |
| 16:30 - 17:30 |
Plenary
Lecture 3
Novel aspects of genetic diseases of bone and kidney
Rajesh V Thakker
|
| 17:30 - 18:30 |
Abbott
Symposium: Evidence for a New Treatment Paradigm in the Management of CKD |
| |
Evening Free |
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| Time |
Saturday,
October 14, 2006 |
| 08.30
- 09.30 |
Plenary
Lecture 4
Calcimimetics
Steven Hebert |
| 09:30
- 10:00 |
Coffee & Networking
Break
|
| 10:00
- 11:30 |
Basic
Science Sessions 2 |
Clinical
Sessions 2 |
Receptors
and cellular mechanism of regulation
Chair: Steven Hebert
- Calcium-sensing receptors
L Darryl Quarles
- Molecular and physiologic consequences of genetic alterations in
the 25-Hydroxyvitamin D3 1α Hydroxylase and the vitamin D receptor
David Goltzman
- Parathyroid cell biology in chronic renal failure
Mariano Rodriguez
|
Osteoporosis and renal osteodystrophy
Chair: Klaus Ølgaard
- Osteoporosis: assessment of fracture risk
Susan Ott
- The new renal osteodystrophy: CKD-MBD (mineral bone disorder)
Sharon Moe
- Is there a role for bisphosphonates in the treatment of renal bone
disease?
Paul Miller
|
| 11:30 - 12:30 |
Shire
Symposium: Assessing the effects of phosphate binders on bone |
| 12:30
- 13:30 |
Lunch & Networking
Break |
| 13.30
- 14.30 |
Poster
Session & Discussion
|
| 14.30 - 16:00 |
Translational
Sessions 2
|
Molecular aspects
of mineral metabolism diseases
Chair: Rajesh V Thakker
- Dent disease and related disorders
Steven J Scheinman
- Pseudohypoparathyroidism, McCune Albright syndrome and the GS alpha
mutations
Harald Jueppner
- Nephrectomized CYP27B1-deficient mice as a model of vitamin D
deficiency and uremia
René St-Arnaud
|
| 16:00 - 16:30 |
Coffee & Networking
Break |
| 16:30 - 17:30 |
Plenary Lecture 5
Bone-kidney axis and vascular calcification
Catherine M Shanahan |
| 17:30 - 18:30 |
Genzyme
Symposium: Current Perspectives on Phosphate |
| |
Evening Free |
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| Time |
Sunday,
October 15, 2006 |
| 08.30
- 09.30 |
Plenary
Lecture 6
Stem cells, PTH and bone
Paolo Bianco |
| 09:30
- 10:00 |
Coffee & Networking
Break
|
| 10:00
- 11:30 |
Basic
Science
Sessions 3 |
Clinical
Sessions 3
|
Phosphatonins
Chair: Rajiv Kumar
- FGF-23: from cloning to function
Takeyoshi Yamashita
- Frizzled-related protein-4 and MEPE in phosphate homeostasis
Rajiv Kumar
- Klotho: bone, kidney, vessels and the ageing process
Makoto Kuro-O
|
Relation
between bone/mineral metabolism disturbances & cardiovascular
disease in CKD and management
Chair: Eberhard Ritz
- Role of FGF-23 in CKD
Masafumi Fukagawa
- Bone histomorphometry and vascular dysfunction
Gérard London
- Vitamin D versus calcimimetics in control of secondary hyperparathyroidism
Klaus Ølgaard
|
| 11:30 - 12:30 |
Leo
Pharma
Symposium: Patient Strategies 2006 and Beyond – Do we Need Alfacalcidol Anymore? |
| 12:30
- 13:30 |
Lunch & Networking
Break |
| 13.30
- 14.30 |
Translational
Sessions 3 |
Pediatric
renal osteodystrophy: unique challenges in the growing
skeleton
Chair: Craig B Langman
- Dynamic aspects of bone growth in children with chronic kidney
disease: lessons learned from innovative imaging techniques
Mary Leonard
- Growth hormone and bone in chronic kidney disease
Burkhard Tönshoff
- Phosphate homeostasis in early chronic kidney disease in children:
role of FGF-23
Craig B Langman
- Effect of vitamin D treatment on parathyroid and bone in children
Isidro Salusky
- Panel Discussion
|
| 14.30 - 15:30 |
Translational
Sessions 4 |
Enzymes, growth
factors and hormones, physiological roles and contributions
to kidney and bone diseases
Chair: Jürgen Floege
- PTH and PTHrP: from mouse to man
Ewa Lewin
- Pathogenesis of vascular calcification: experimental studies in
vitro and in vivo
Dwight A Towler
- Pathogenesis and treatment of vascular calcification in CKD patients
Markus Ketteler
|
| 15:30 - 16:00 |
Closing
Remarks: Heini Murer |
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Departure |
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